Wow! I just learned how to play Atlantis by Mayfair Games and Quirkle, winner of multiple awards. They are both really great, and I am lucky enough to have a family that doesn't mind being my (and your) game guinea pigs! Quirkle resembles Scrabble, but instead of letters and words, uses colors and shapes. It is loosely based on dominoes, but with two elements instead of one. What is so great about this game is that you don't need to know how to spell, and it builds visual acuity in small people around your home. My 6 year old son is great at this game. It's often challenging to find a game to appeal to kids and adults. Quirkle rises to the challenge.
Atlantis is another gem by renowned game company Mayfair - of Settlers of Catan fame. Atlantis is easy to learn and quick to play. You are following a trail from Atlantis to the mainland while collecting points and treasure, and attempting to foil your opponent. Unlike many strategy intensive games, this one is enjoyable with only 2 people, but has space for up to 4 players.